When used for the treatment of high blood pressure, it is
effective alone or combined with other high blood pressure
medications, particularly thiazide-type diuretics. Beta blockers
decrease the force and rate of heart contractions, reducing
the heart's demand for oxygen and lowering blood pressure.
How Is It Used?
Inderal works best when taken before meals.
Take it exactly as prescribed, even if your symptoms have
disappeared.
Try not to miss any doses. If this medication is not taken
regularly, your condition may worsen.
Most important fact
about this drug
If you have high blood pressure, you must
take Inderal regularly for it to be effective. Since blood
pressure declines gradually, it may be several weeks before
you get the full benefit of Inderal; and you must continue
taking it even if you are feeling well. Inderal does not cure
high blood pressure; it merely keeps it under control.
Are There Possible
Side Effects?
Side effects cannot be anticipated. If
any develop or change in intensity, inform your doctor as
soon as possible. Only your doctor can determine if it is
safe for you to continue taking Inderal.
- Side effects may include:
Abdominal cramps, colitis, congestive heart failure, constipation,
decreased sexual ability, depression, diarrhea, difficulty
breathing, disorientation, dry eyes, fever with sore throat,
hair loss, hallucinations, headache, light-headedness, low
blood pressure, lupus erythematosus (a disease of the connective
tissue), nausea, rash, reddish or purplish spots on the
skin, short-term memory loss, slow heartbeat, tingling,
prickling in hands, tiredness, trouble sleeping, upset stomach,
visual changes, vivid dreams, vomiting, weakness, worsening
of certain heartbeat irregularities.
Why should this drug
not be prescribed?
If you have inadequate blood supply to
the circulatory system (cardiogenic shock), certain types
of irregular heartbeat, a slow heartbeat, bronchial asthma,
or severe congestive heart failure, you should not take this
medication
Special warnings
about this medication
If you have a history of congestive heart failure, your doctor
will prescribe Inderal cautiously.
Inderal should not be stopped suddenly. This can cause increased
chest pain and heart attack. Dosage should be gradually reduced.
If you suffer from asthma or other bronchial conditions, coronary
artery disease, or kidney or liver disease, this medication
should be used with caution.
Ask your doctor if you should check your pulse while taking
Inderal. This medication can cause your heartbeat to become
too slow.
This medication may mask the symptoms of low blood sugar or
alter blood sugar levels. In addition, diabetics who experience
a severe drop in blood sugar after taking insulin may suffer
a spike in blood pressure if they are also taking Inderal.
Notify your doctor or dentist that you are taking Inderal
if you have a medical emergency, and before you have surgery
or dental treatment.
What
About Interactions With Other Drugs?
If Inderal is taken with certain other drugs, the effects
of either could be increased, decreased, or altered. It is
especially important to check with your doctor before combining
Inderal with the following:
- Alcohol
- Aluminum hydroxide gel (Amphojel)
- Antipyrine (Auralgan)
- Calcium-blocking blood pressure drugs such as Cardizem,
Procardia, and Calan
- Certain high blood pressure medications such as Diupres
and Ser-Ap-Es
- Chlorpromazine (Thorazine)
- Cimetidine (Tagamet)
- Epinephrine (EpiPen)
- Haloperidol (Haldol)
- Insulin
- Lidocaine (Xylocaine)
- Nonsteroidal anti-inflammatory drugs such as Motrin and
Naprosyn
- Oral diabetes drugs such as Micronase
- Phenobarbitone
- Phenytoin (Dilantin)
- Rifampin (Rifadin)
- Theophylline (Theo-Dur and others)
- Thyroid medications such as Synthroid
Special information
if you are pregnant or breastfeeding
The effects of Inderal during pregnancy have not been adequately
studied. If you are pregnant or plan to become pregnant, inform
your doctor immediately. Inderal appears in breast milk and
could affect a nursing infant. If this medication is essential
to your health, your doctor may advise you to discontinue
breastfeeding until your treatment with this medication is
finished.
Recommended dosage
ADULTS
All dosages of Inderal, for any problem, must be tailored
to the individual. Your doctor will determine when and how
often you should take this drug. If you are over 65, the doctor
will probably start with a relatively low dosage. Remember
to take it exactly as directed.
Hypertension
The usual starting dose is 40 milligrams 2 times a day. This
dose may be in combination with a diuretic. Dosages are gradually
increased to between 120 milligrams and 240 milligrams per
day for maintenance. In some cases, a dose of 640 milligrams
per day may be needed. Depending on the individual, maximum
effect of this drug may not be reached for a few days or even
several weeks. Some people may do better taking this medication
3 times a day.
Angina Pectoris
The usual daily dosage is 80 milligrams to 320 milligrams,
divided into 2, 3, or 4 smaller doses. When your treatment
is being discontinued, your doctor will reduce the dosage
gradually over a period of several weeks.
Irregular Heartbeat
The usual dose is 10 milligrams to 30 milligrams 3 or 4 times
a day, before meals and at bedtime.
Heart Attack
The usual daily dosage is 180 milligrams to 240 milligrams
divided into smaller doses. The usual maximum dose is 240
milligrams, although your doctor may increase the dose when
treating heart attack with angina or high blood pressure.
Migraine
The usual starting dosage is 80 milligrams per day divided
into smaller doses. Dosages can be increased gradually to
between 160 milligrams and 240 milligrams per day. If this
dose does not relieve your symptoms in 4 to 6 weeks, your
doctor will slowly take you off the drug.
Tremors
The usual starting dose is 40 milligrams, 2 times per day.
Symptoms will usually be relieved with a dose of 120 milligrams
per day; however, on occasion, dosages of 240 milligrams to
320 milligrams per day may be necessary.
Hypertrophic Subaortic Stenosis
The usual dose is 20 milligrams to 40 milligrams, 3 to 4 times
a day, before meals and at bedtime.
Before Adrenal Gland Surgery
The usual dose is 60 milligrams a day divided into smaller
doses for 3 days before surgery in combination with an alpha-blocker
drug.
Inderal may also be taken by people with inoperable tumors
in doses of 30 milligrams a day, divided into smaller doses.
CHILDREN
Inderal will be carefully individualized for use in children
and is used only for high blood pressure. Doses in children
are calculated by body weight, and range from 2 milligrams
to 4 milligrams per 2.2 pounds daily, divided into 2 equal
doses. The maximum dose is 16 milligrams per 2.2 pounds per
day.
If treatment is stopped, this drug must be gradually reduced
over a 7- to 14-day period.
Inderal is also available in a sustained-release formulation,
called Inderal LA, for once-a-day dosing.
In case of emergency/overdose
No specific information on Inderal
overdosage is available; however, overdose symptoms with other
beta blockers include:
- Extremely slow heartbeat,
- Irregular heartbeat,
- Low blood pressure,
- Severe congestive heart failure,
- Seizures, wheezing
Any medication taken in excess can have serious
consequences. If you suspect an overdose, seek medical attention
immediately.
What If I Miss A Dose?
Take it as soon as you remember. If it
is within 8 hours of your next scheduled dose, skip the one
you missed and go back to your regular schedule. Never take
2 doses at the same time.
How Should It Be
Stored?
Store at room temperature in a tightly closed, light-resistant
container. Protect from freezing or excessive heat.
NOTE: The above
information is intended to supplement, not substitute for,
the expertise and judgment of your physician, pharmacist,
or other healthcare professional. It should not be construed
to indicate that the use of the product is safe, appropriate,
or effective for you. Consult your healthcare professional
before taking the product. |