Simvastatin
Generic Name:
Simvastatin
Typical Brand Name(s): Zocor
What Is It
Used For?
SIMVASTATIN (Zocor) blocks the body's ability to make cholesterol.
Simvastatin can help lower blood cholesterol for patients who are
at risk of getting heart disease or a stroke. It is only for patients
whose cholesterol level is not controlled by diet. Generic simvastatin
tablets are not yet available.
How Is It Used?
Take simvastatin tablets by mouth. Follow the
directions on the prescription label. Swallow the tablets with a
drink of water. If you take the tablets once a day, it is best to
take your dose in the evening hours (like with the evening meal)
or at bedtime. You may take this medicine with or without food.
Do not take simvastatin with grapefruit juice; orange juice may
be used instead. Take your doses at regular intervals. Do not take
your medicine more often than directed.
Contact your pediatrician or health care professional
regarding the use of this medicine in children. Special care may
be needed.
What should my health care
professional know before I take Simvastatin?
They need to know if you have any of these conditions:
- An Alcohol problem
- Any Hormone Disorder (such as diabetes, under-active
thyroid)
- Blood Salt Imbalance
- Infection
- Kidney Disease
- Liver Disease
- Low Blood Pressure
- Muscle Disorder or Condition
- Recent Surgery
- Seizures (convulsions)
- Severe Injury
- An unusual or allergic reaction to simvastatin,
other medicines, foods, dyes, or preservatives
- Pregnant or trying to get pregnant
- Breast-Feeding
Are There Possible Side
Effects?
Side effects that you should report to your prescriber
or health care professional as soon as possible:
Rare or uncommon:
- Dark Yellow or Brown urine
- Decreased Urination, difficulty passing urine
- Fever
- Muscle Pain, Tenderness, Cramps, or Weakness
- Redness, Blistering, Peeling or Loosening of the
skin, including inside the mouth
- Skin Rash, Itching
- Unusual tiredness or weakness
- Yellowing of the skin or eyes
Side effects that usually do not require medical attention
(report to your prescriber or health care professional if they continue
or are bothersome):
- Constipation
- Headache
- Upset Stomach, Indigestion, Gas, Heartburn
What
About Interactions With Other Drugs?
Do not take Simvastatin with any of the following:
- Amprenavir
- Atazanavir
- Clarithromycin
- Delavirdine
- Erythromycin
- Grapefruit juice
- Indinavir
- Itraconazole
- Ketoconazole
- Lopinavir; ritonavir
- Mibefradil
- Nefazodone
- Nelfinavir
- Ritonavir
- Saquinavir
- Went Yeast
Simvastatin may also interact with the following medications:
- Alcohol
- Amiodarone
- Barbiturates (examples: phenobarbital, butalbital,
primidone)
- Bosentan
- Carbamazepine
- Cyclosporine
- Digoxin
- Diltiazem
- Efavirenz
- Fluconazole
- Medicines to lower cholesterol or triglycerides
(examples: fenofibrate, gemfibrozil, niacin)
- Medicine used to stop early pregnancy (mifepristone,
RU-486)
- Nicardipine
- Oxcarbazepine
- Phenytoin
- Rifampin, rifabutin, or rifapentine
- St. John's Wort
- Telithromycin
- Troleandomycin
- Verapamil
- Voriconazole
- Warfarin
Tell your prescriber or health care professional about
all other medicines you are taking, including non-prescription medicines,
nutritional supplements, or herbal products. Also tell your prescriber
or health care professional if you are a frequent user of drinks
with caffeine or alcohol, if you smoke, or if you use illegal drugs.
These may affect the way your medicine works. Check with your health
care professional before stopping or starting any of your medicines.
What should I watch for while
taking Simvastatin?
Visit your prescriber or health care professional
for regular checks on your progress. You may need to have blood
tests drawn to make sure your liver is working properly.
Tell your prescriber or health care professional as soon
as you can if you get any unexplained muscle pain, tenderness, or
weakness, especially if you also have a fever and tiredness.
Some medicines increase the risk of muscle side effects while taking
simvastatin. Discuss your drug regimen with your health care provider
if you are prescribed certain antibiotics or antifungals which are
not recommended to be taken with simvastatin (examples: clarithromycin,
erythromycin, itraconazole, ketoconazole). Your prescriber may decide
to temporarily stop taking simvastatin while you are taking a short
course of the antibiotic or antifungal therapy. Alternatively, your
health care provider may prescribe another antibiotic or antifungal
medicine for your condition.
Simvastatin is only part of a total cholesterol-lowering program.
Your physician or dietician can suggest a low-cholesterol and low-fat
diet that will reduce your risk of getting heart and blood vessel
disease. Avoid alcohol and smoking, and keep a proper exercise schedule.
If you are going to have surgery tell your prescriber or health
care professional that you are taking simvastatin.
What If I Miss A Dose?
If you miss a dose, take it as soon as you can.
If it is almost time for your next dose, take only that dose. Do
not take double or extra doses.
How Should It Be Stored?
Keep out of the reach of children in a container
that small children cannot open.
Store at room temperature between 5?30 degrees C (41?86
degrees F). Throw away any unused medicine after the expiration
date. NOTE: The above information
is intended to supplement, not substitute for, the expertise and
judgment of your physician, pharmacist, or other healthcare professional.
It should not be construed to indicate that the use of the product
is safe, appropriate, or effective for you. Consult your healthcare
professional before taking the product.
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